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The 25th International Fibrinogen Conference & 3rd Factor XIII Workshop is pleased to share the abstracts submitted for presentation. All abstracts have been reviewed by a panel of fifteen experts. Each abstract was independently scored by three reviewers. Please find below an alphabetical list of abstracts for oral presentations and posters, based on the ranking by reviewers.

Abstracts listed in alphabetical order by presenter

Other Authors TitlePresentation
 Acquasaliente L. Pelc, E. Ruben, E. Di Cera Characterization of a catalytically active thrombin precursor generated by non-canonical proteolytic activation


 Alummoottil M.N. Phasha (1); J. Bester (1); E. Pretorius (2); A. Phulukdaree (1) Ultrastructural evaluation of clot properties and mRNA levels of clotting factor XIII in asthma patients Poster
 Ariens Fibrin polymerizes into films with important physiological functions
 State of the Art
 AsquithDuval C.(1), Baker S.(1) Domingues M.M.(1,2), McPherson1 H.R., Macrae F.L (1), Connell S.D.(3), Barsegov V. (4), Ariëns R.A.S. (1)
Extended D-E interactions near the classical knob-hole binding site play an important role in fibrin polymerisation and clot stability Oral
 BagolyB. Baráth, I. Szegedi, R. Kálmándi, L. Csiba, É. Katona
 Incorporation of alpha2-plasmin inhibitor into fibrin clots and its association with the clinical outcome of acute ischemic stroke patients
 BakerC. Duval and R. A.S. Ariëns
Comparison of three fibrinogen preparations, implications of protein homogeneity on clot formation, structure and stability
 BakerA. Undas (2), R. A. S. Ariëns (1)
Patients with recurrent Venous Thromboembolism (VTE) have less elastic clots than those with non-recurrent VTE
 BanerjeeS. Yakovlev (2), J. M. Gruschus (1), L. Medved (2), and N. Tjandra (1)
Structural insight into interaction of fibrin with the very low density lipoprotein receptor
 BannishJ. W. Weisel, A. L. Fogelson
The effect of plasmin-mediated degradation on tPA diffusion and fibrinolysis: a mathematical approach
 BychkovaA.D. Vasilyeva, L.V. Yurina, M.A. Rosenfeld
Oxidation of fibrinogen and fibrin-stabilizing factor: random or programmed processes
 CarvalhoA.F. Guedes (1), C. Moreira (2), A.C. Fonseca (1,2), J.B.Nogueira (2), J.M. Ferro (1,2), N.C. Santos (1)
Arterial hypertension and stroke patients present higher erythrocyte adhesion forces, contributing to fibrinogen-dependent cardiovascular risk
 Carvalho, Santos A.F. Guedes(1), C. Duval (2), F. Macrae(2), L. Swithenbank(2), D.H. Farrell (3), R.A.S. Ariëns(2)The 94RGD97 sequence on the Aα chain of fibrinogen is essential for the binding to its erythrocyte receptor
 CeznerováJ. Štikarová, J. Suttnar, Ž. Sovová, J. Loužil, R. Kotlín, P. Salaj, J. E. Dyr
Fibrinogen Liberec II – dysfibrinogenemia caused by Y211H mutation
 Christenson, UgarovaN. Podolnikova 2 , V. Lishko 2 , R. Ros 1

Quantifying adhesion of platelets to fibrin(ogen) substrates using single cell force spectroscopy
 De LangeKahler, C.M. Smuts & M. Pieters
Composite and individual phospholipid fatty acids associate with pro-thrombotic and pro-fibrinolytic clot properties in a healthy African population
 DementN. E. Hudson
Examining the αC Connector and its role on Fibrin Polymerization and Extensibility
 DempfleM. M. Müller, P. Fürner, B. Thiele
Common calibration of D-dimer assays based on detection of dimerized D-domains
 DempfleM. . Müller, B. Thiele
Measurement of fibrinogen concentration - rapid assays needed for the emergency room and ICU
 State of the Art
 DuvalM. Ali, S. Baker, F. Macrae, V.C. Ridger, R.A.S. Ariëns
Fibrin g-chain cross-linking increases clot stiffness and protects against embolization as demonstrated in a new genetically modified murine model
 Duval, RoccoA. Profumo (2) A. Aprile (2) A. Salis (3) G. Damonte (3) R. Ariëns (1)
A "double-Detroit" fibrinogen recombinant mutant with completely impaired polymerization following fibrinopeptides cleavage.
 FlickLuyendyk, Flick, A. K. Kopec, S. R. Abrahams, J. S. Palhumbo, S. DivanovicFibrin mediates metabolic changes that promote diet-induced obesityState of the Art
 Fuquay, Hudson Elongation of fibrin fibers during fibrinolysis
 GalanakisC. Marmorat, A. Protopopova, M. Refailovich, J.W. Weisel
Initiation of adsorption-induced fibrin self-assembly and its relationship to soluble fibrin aggregates
 GutholdC. C. Helms, S. R. Baker, J. Sigley, E. Voyles, S. Banerjee, J. Sharpe, Z. Zhang, J. Diaz-Silveira, K. Bonin
The mechanical properties of electrospun fibrinogen, blended fibrinogen:PCL and fibrinogen:collagen nanofibers
 Hawkins, Lamer N. Badiei, B.R. Thomas, P.R. Williams
 The role of clot microstructure in the non-linear viscoelastic properties of fibrin clots.
 State of the Art
 Hein, White Reversal of fibrinolysis by tranexamic acid is dependent upon fibrinogen concentration.
 KattulaM. S. Flynn(1), Z. Bagoly(2), N. K. Tóth(2), L. Muszbek(2), and A. S. Wolberg(1)
Factor XIII Val34Leu polymorphism is associated with the formation of smaller whole blood clots at high fibrinogen levels
 KattulaB. C. Cooley, and A. S. Wolberg
Novel venous thromboembolism mouse model to evaluate pulmonary embolism risk
 KinneyK. Bonin1,2, R. Cubicciotti2, M. Guthold1,2,*
Turbidimetry measurements of plasma clots from healthy males and males with cardiovascular disease on low or medium dose aspirin
 Koopman, FlickO. Negron 2,  Weggeman 1 , L. Huisman 1 , A. Stang 2 , and M. J. Flick 2
A human fibrinogen variant with impaired Staphylococcus aureus binding function
promotes host survival during septicemia in mice.

E. Ceznerová, J. Loužil, J. Štikarová, J. Suttnar, O. Pastva, P. Salaj. J. E. Dyr
Dysfibrinogenemias in the Czech Republic
 LammL. W. Chan(1), X. Wang(2), S. H. Pun(1) N. J. White(2)
PolySTAT is a clinically-relevant, tunable fibrin cross-linking material for the treatment of traumatic bleeding
 State of the Art
 Lishko (Ugarova)H. Owaynat, J. Faust,  T. Ugarova
The dual role of platelets in thrombus formation
 LitvinovP. Hook(2), J. S. Bennett(1), J. W. Weisel(1)

Fibrinogen, monomeric and polymeric fibrin differentially interact with the platelet integrin αIIbβ3
 Litvinov, BarsegovO. Kononova(3), A. Zhmurov(4), K. A. Marx(3), V. Barsegov(4), and J. W. Weisel(1)
Molecular mechanism of transition from catch bonds to slip bonds in fibrin
 LouzilSalaj. P., Kotlín R., Dyr J.E., Ceznerova E., Hrachovinova I.

Dysfibrinogenemia and hypofibrinogenemia from clinical point of view
 Martinez-TorresG.H. Koenderink

Mechanosensitive lysis of single fibrin fibers
 MartiniM. A. Dubick
Coagulation Restoration by Fibrinogen Concentrate after Platelet Reduction and Traumatic Hemorrhage in Pigs
 Maurer Anokim, Maurer, V. Stribinskis, W.L. Dean Structural Rearrangements and Catalytic Competence of Factor XIII as a Funciton of Activation Pathway State of the Art
 Medved  What do we know about the molecular mechanisms of fibrin(ogen)-dependent inflammation?

State of the Art

 MisztaJ. R. Byrnes(1), M. J. Flick(3), B. de Laat(2), A. S. Wolberg(1)
Measurement of in situ plasmin generation in murine plasma reveals dependency on fibrin formation and plasminogen-fibrin interactions
Neerman-Arbez Neerman-ArbezFibrinogen gene variants in monogenic and complex diseases
 State of the Art
 NellenbachN. Guzzetta(3) , A.C. Brown(1,2)
Analysis of the structural and mechanical effects of pro-thrombotic agents on neonatal fibrin networks following cardiopulmonary bypass.
 PhashaP. Soma (1), E. Pretorius (2) A. Phulukdaree (1)
Assessing gene expression of coagulation factors and Factor XIII polymorphisms in type 2 diabetes mellitus patients
 PietersC. Ricci, A.E. Schutte, Z. de Lange
Plasma fibrin clot properties are associated with cardiovascular function decline and mortality – a 10 year prospective, population-based analysis
 State of the Art
 Poole A.K. Kopec 1,2 , M.J. Flick 3 , and J.P. Luyendyk 1,2
 Tissue transglutaminase cross-linking activity enhances fibrin(ogen)-driven pro-inflammatory gene expression in macrophages Oral
 ProtopopovaA. Ramirez, R. I. Litvinov, J. W. Weisel
Structure of factor XIII and its subunits revealed by atomic force microscopy
 RescignoG. Rosa
Leukocyte-Platelet Rich Fibrin (L-PRF) in the treatment of skin lesions.
 RicottaY. Yu, C.-C. Chang , D. K. Galanakis, K. Levon,
M. Rafailovich
Design of a 3-D molecular imprinting biosensor  with multi-scale roughness for the detection of fibrinogen Poster
Sharpe, Zhang
J. Diaz-Silveira, K. Bonin, M. Guthold*
The mechanical properties of electrospun, blended fibrinogen:PCL nanofibers
 SilvaN. Dutzan(2), A. G. Lum (2), M. Sibree1, T. Greenwell-Wild (2), F. J. Castellino(3), M. J. Flick(4), N. Moutsopoulos(2) and T. H. Bugge(1)
Fibrin is a critical regulator of immunopathology at the oral mucosal barrier
 StielerC. Büchold, A. Heine, M. Hils, G. Klebe, R. Pasternack, J. Weber
Calcium-Induced Activation of FXIII and Structure-Based Design of Direct Acting Inhibitors
 ŠtikarováJ. Suttnar, E. Ceznerová, P. Májek, J. Loužil, Ž. Sovová, R. Kotlín, J. E. Dyr
Model oxidative modification of fibrinogen and the influence on its functionPoster
A. D. Peshkova(2), G. Le Minh, S. Zaytsev(1), R. I. Litvinov(1,2), D. B. Cines(1), J. W. Weisel(1)
Distinctive fibrinolysis in contracted versus uncontracted blood clots
 State of the Art
 TutwilerA. D. Peshkova (2), G. Le Minh, I. A. Andrianova(2), J. W. Weisel(1), R. I. Litvinov(1,2)
Reduced contraction of venous thrombi may increase their obstructiveness and embologenicity.
 van Dijk, Donkel T. Zadi (1), M.A.H. Sonneveld (3), F.H.B.M. Schreuder (4,5), M.F. Chohan (3), P.J. Koudstaal (2), F.W.G. Leebeek (3), R. Saxena (6), J. Hendrikse, (7), M.E. Kooi (8,9), A. van der Lugt,(1), M P.M. de Maat,(3)
Imaging Biomarkers of Atherosclerosis in Stroke Patients are Associated with Fibrinogen and Fibrinogen γ’: The Plaque At RISK Study (PARISK).
 VasilyevaL.V. Yurina(1), A.V. Bychkova(1), M.I. Indeykina(1,2,3), A.E. Bugrova(1), A.S. Kononikhin(1,2,3), E.N. Nikolaev(1,2,4), M.A. Rosenfeld(1)
Free-radical oxidation of plasma fibrin-stabilizing factor: structural and functional features, antioxidant self-defense
 VeenC. Nagaswami(2), J.W. Weisel(2), M.J.H.A. Kruip(1), M.P.M. de Maat(1)

Abnormal fibrin clot structure in women who experienced postpartum hemorrhage
 WangYJ Wang, M Bonn, S Parekh Shear-deformed fibrin hydrogel fiber alignment and secondary structural transition by coherent Raman Scattering Poster
 WeiselJ WeiselCellular mechanisms of clot contraction and some clinical consequences
 State of the Art
 YakovlevL. Medved
Identification of fibrin(ogen) species involved in stimulation of the VLDL receptor-dependent transendothelial migration of leukocytes
 Yesudasan R. D. Averett
Reactive Dissipative Particle Dynamics Method for Simulating Fibrin Clot Polymerization
 YurinaA.D. Vasilyeva(1), A.V. Bychkova(1), A.E. Bugrova1, M.I. Indeykina(1,2,3), N.A. Podoplelova(5,6), A.S. Kononikhin(1,2,3), E.N. Nikolaev(1,2,4), M.A. Panteleev(5,6), M.A. Rosenfeld(1)
Free radical oxidation of fibrinogen molecules: their oxidative modification and the effect on conversion to fibrin Poster
 B. Casey, D. K. Galanakis, C. Marmorat, S. Skoog, K. Vorvolakos , M. Simon, M. H. Rafailovich
The influence of surface wetting properties on adsorbed fibrinogen conformation, orientation, fibrilogenesis and platelet adhesion
A. D. Protopopova (2), R. I. Litvinov(2,3), V. Barsegov(4,1), J. W. Weisel(2)
Atomic structure of fibrin protofibrils

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